1.I.6E

Mathematical Biology
Part II, 2005

Consider a biological system in which concentrations x(t)x(t) and y(t)y(t) satisfy

dxdt=f(y)x and dydt=g(x)y\frac{d x}{d t}=f(y)-x \quad \text { and } \quad \frac{d y}{d t}=g(x)-y

where ff and gg are positive and monotonically decreasing functions of their arguments, so that xx represses the synthesis of yy and vice versa.

(a) Suppose the functions ff and gg are bounded. Sketch the phase plane and explain why there is always at least one steady state. Show that if there is a steady state with

lnflnylnglnx>1\frac{\partial \ln f}{\partial \ln y} \frac{\partial \ln g}{\partial \ln x}>1

then the system is multistable.

(b) If f=λ/(1+ym)f=\lambda /\left(1+y^{m}\right) and g=λ/(1+xn)g=\lambda /\left(1+x^{n}\right), where λ,m\lambda, m and nn are positive constants, what values of mm and nn allow the system to display multistability for some value of λ\lambda ?

Can f=λ/ymf=\lambda / y^{m} and g=λ/xng=\lambda / x^{n} generate multistability? Explain your answer carefully.