2.II.13E

Mathematical Biology
Part II, 2005

Consider the reaction-diffusion system

uτ=βu(u2vu)+Du2ux2vτ=βv(u2v)+Dv2vx2\begin{aligned} &\frac{\partial u}{\partial \tau}=\beta_{u}\left(\frac{u^{2}}{v}-u\right)+D_{u} \frac{\partial^{2} u}{\partial x^{2}} \\ &\frac{\partial v}{\partial \tau}=\beta_{v}\left(u^{2}-v\right)+D_{v} \frac{\partial^{2} v}{\partial x^{2}} \end{aligned}

for an activator uu and inhibitor vv, where βu\beta_{u} and βv\beta_{v} are degradation rate constants and DuD_{u} and DvD_{v} are diffusion rate constants.

(a) Find a suitably scaled time tt and length ss such that

ut=u2vu+2us21Qvt=u2v+P2vs2\begin{aligned} \frac{\partial u}{\partial t} &=\frac{u^{2}}{v}-u+\frac{\partial^{2} u}{\partial s^{2}} \\ \frac{1}{Q} \frac{\partial v}{\partial t} &=u^{2}-v+P \frac{\partial^{2} v}{\partial s^{2}} \end{aligned}

and find expressions for PP and QQ.

(b) Show that the Jacobian matrix for small spatially homogenous deviations from a nonzero steady state of ()(*) is

J=(112QQ)J=\left(\begin{array}{cc} 1 & -1 \\ 2 Q & -Q \end{array}\right)

and find the values of QQ for which the steady state is stable.

[Hint: The eigenvalues of a 2×22 \times 2 real matrix both have positive real parts iff the matrix has a positive trace and determinant.]

(c) Derive linearised ordinary differential equations for the amplitudes u^(t)\hat{u}(t) and v^(t)\hat{v}(t) of small spatially inhomogeneous deviations from a steady state of ()(*) that are proportional to cos(s/L)\cos (s / L), where LL is a constant.

(d) Assuming that the system is stable to homogeneous perturbations, derive the condition for inhomogeneous instability. Interpret this condition in terms of how far activator and inhibitor molecules diffuse on average before they are degraded.

(e) Calculate the lengthscale Lcrit L_{\text {crit }} of disturbances that are expected to be observed when the condition for inhomogeneous instability is just satisfied. What are the dominant mechanisms for stabilising disturbances on lengthscales (i) much less than and (ii) much greater than Lcrit L_{\text {crit }} ?