1.I.6B

Mathematical Biology
Part II, 2008

A gene product with concentration gg is produced by a chemical SS of concentration ss, is autocatalysed and degrades linearly according to the kinetic equation

dgdt=f(g,s)=s+kg21+g2g\frac{d g}{d t}=f(g, s)=s+k \frac{g^{2}}{1+g^{2}}-g

where k>0k>0 is a constant.

First consider the case s=0s=0. Show that if k>2k>2 there are two positive steady states, and determine their stability. Sketch the reaction rate f(g,0)f(g, 0).

Now consider s>0s>0. Show that there is a single steady state if ss exceeds a critical value. If the system starts in the steady state g=0g=0 with s=0s=0 and then ss is increased sufficiently before decreasing back to zero, show that a biochemical switch can be achieved to a state g=g2g=g_{2}, whose value you should determine.