1.I.6B
Part II, 2008
A gene product with concentration is produced by a chemical of concentration , is autocatalysed and degrades linearly according to the kinetic equation
where is a constant.
First consider the case . Show that if there are two positive steady states, and determine their stability. Sketch the reaction rate .
Now consider . Show that there is a single steady state if exceeds a critical value. If the system starts in the steady state with and then is increased sufficiently before decreasing back to zero, show that a biochemical switch can be achieved to a state , whose value you should determine.