Paper 3, Section II, C

Mathematical Biology
Part II, 2019

(a) A stochastic birth-death process has a master equation given by

dpndt=λ(pn1pn)+β[(n+1)pn+1npn]\frac{d p_{n}}{d t}=\lambda\left(p_{n-1}-p_{n}\right)+\beta\left[(n+1) p_{n+1}-n p_{n}\right]

where pn(t)p_{n}(t) is the probability that there are nn individuals in the population at time tt for n=0,1,2,n=0,1,2, \ldots and pn=0p_{n}=0 for n<0n<0.

(i) Give a brief interpretation of λ\lambda and β\beta.

(ii) Derive an equation for ϕt\frac{\partial \phi}{\partial t}, where ϕ\phi is the generating function

ϕ(s,t)=n=0snpn(t)\phi(s, t)=\sum_{n=0}^{\infty} s^{n} p_{n}(t)

(iii) Assuming that the generating function ϕ\phi takes the form

ϕ(s,t)=e(s1)f(t)\phi(s, t)=e^{(s-1) f(t)}

find f(t)f(t) and hence show that, as tt \rightarrow \infty, both the mean n\langle n\rangle and variance σ2\sigma^{2} of the population size tend to constant values, which you should determine.

(b) Now suppose an extra process is included: kk individuals are added to the population at rate ϵ(n)\epsilon(n).

(i) Write down the new master equation, and explain why, for k>1k>1, the approach used in part (a) will fail.

(ii) By working with the master equation directly, find a differential equation for the rate of change of the mean population size n\langle n\rangle.

(iii) Now take ϵ(n)=an+b\epsilon(n)=a n+b for positive constants aa and bb. Show that for β>ak\beta>a k the mean population size tends to a constant, which you should determine. Briefly describe what happens for β<ak\beta<a k.